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10.1016/j.jnutbio.2018.02.012 104

FASN drives de novo lipogenesis, contributing to the formation and accumulation of lipids within LDs [118]

The N-terminal tripeptide deletion in IGF-1 DES dramatically reduces its binding affinity for all IGFBPs by approximately 100-fold or more, while preserving or even slightly enhancing its affinity for the IGF-1 receptor itself