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The liver plays a vital role in methylation and detoxification

[12] Furthermore, patients suffering from chronic diseases who require frequent dosing would greatly benefit from alternative administration routes

Magnetic resonance imaging has shown that the lens microcirculation system can deliver solutes to the lens nucleus faster than is predicted to occur via passive diffusion alone

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By integrating mechanistic insights with preclinical and emerging clinical evidence, we compared lipid-based, polymeric, vesicular, and dendritic nanocarriers, highlighting how particle size, surface chemistry, and ligand functionalization govern bloodbrain barrier transport and intracerebral distribution