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Acknowledgements We acknowledge co-funding from the Fondazione per la Ricerca Biomedica Saverio e Isabella Cianciola and from Next Generation EU, in the context of the National Recovery and Resilience Plan, Investment PE8 Project Age-It: Ageing Well in an Ageing Society

This approval represents the first FDA-approved drug specifically targeting mitochondrial function, establishing regulatory precedent for the mitochondrial dysfunction pathway in aging and neurodegeneration

Preclinical safety evaluation of body protective compound-157

These are the same pathways cancer cells exploit to grow and spread

It should be emphasized that exceeding the cutoff weight loss of 15 Percentage is of great clinical importance