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As reported by Blaabjerg and his co-workers, the ability of probiotics to preserve and restore gut homeostasis has been demonstrated in a wide range of disorders characterized by disrupted microbiota (188)

Probiotic supplementation influences gut microbiome health and may reduce inflammation throughout the digestive tract

These cytokines promote cartilage degradation, synovial inflammation, abnormal bone remodeling, and neuropathic sensitization, collectively driving the initiation, progression, and pain associated with OA 10 .Targeted anti-inflammatory therapies represent a critical direction in OA treatment

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FOXO4-DRI has a rapidly expanding and high-impact published research base, with studies published across Nature, Nature Communications, Communications Biology, Aging, Frontiers in Bioengineering and Biotechnology, and PMC since its foundational description in 2017