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1 A meta-analysis of findings from 11 randomized controlled trials found SERM therapy with either clomiphene citrate or tamoxifen improved some sperm parameters and hormone levels, and more than doubled the pregnancy rate in couples affected by idiopathic male infertility

Key Areas of Research Structural: collagen, matrix, tendon Vascular: angiogenesis, nitric oxide, signaling Epithelial: migration, vessel formation, matrix Systemic: signaling, viability, pathway dynamics References Sikiric P

Pharmaceutical pricing exists because companies need to recover R&D costs (often hundreds of millions of dollars per approved drug), navigate regulatory expenses, fund post-approval surveillance, and price against insurance reimbursement schedules

Their high specificity for target receptors or enzymes often results in fewer off-target effects and improved safety profiles