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To overcome this limitation, research efforts have been devoted to the development of therapeutic agents with biological mechanisms of action that are independent of the oxygen concentration

Combined treatments often deliver enhanced benefits through synergistic effects

OS arises from an imbalance between oxidative and antioxidant systems

37 These mechanisms are particularly relevant in IBS, where sensory neuron hypersensitivity contributes to abdominal pain and bloating

Individuals with reduced DHFR activity are more likely to accumulate UMFA and may therefore benefit from using methylfolate or folinic acid instead of folic acid