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2009;20(6):12105 Ho MJ, Bellusci A, Wright JM

In the case of intrinsic apoptosis, which is mainly associated with mitochondrial dysfunction or ER stress, ROS can activate the cell cycle regulators p53 and JNK, which induce pro-apoptotic Bcl-2 family proteins such as Bak and Baxantagonists to anti-apoptotic proteins Bcl-xL and Bcl-2 in the outer mitochondrial membrane (OMM)eventually causing mitochondrial outer membrane permeabilization and subsequent apoptosis [136, 137]

Appl Biochem Biotechnol 168:198205 Wang C, Zhang J, Wu H, Li Z, Ye Q (2015) Heterologous gshF gene expression in various vector systems in Escherichia coli for enhanced glutathione production