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Description

Pharmacokinetic interaction between bedaquiline and clofazimine in patients with drug-resistant tuberculosis

Erythrocyte NAD(H) levels started to saturate already with 500-750 mg of niacin and increasing the dose up to 1000 mg had only a slight additional effect on steady-state NAD + in blood cells

the method comprises reacting an epoxide of formula (XVI-1) bearing a protected hydroxyl group with an amino acid comprising conjugation partner of the formula (III) to provide a compound of the formula (XV-1a)