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Over the past 30 years, advances in psychiatric research have elucidated the numerous effects of GLU and its receptors on neuropsychiatric disorders

These include the overexpression of enzymes involved in fatty acid metabolism, such as acyl-CoA synthetase long-chain family member 4 (ACSL4), antioxidant defense enzymes like glutathione peroxidase 4 (GPX4), transcription factors such as nuclear factor E2-related factor 2 (Nrf2), and plasma membrane repair molecules like the endosomal sorting complexes required for transport III (ESCRT-III) (Chen et al., 2021a)

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Understanding these compounds downstream effects and clinical correlates has advanced significantly

32 Recent studies revealed that gender specific genomic differences in MDD patients, the downregulation of the MDD-related gene Dusp6 in females leads to an increased susceptibility to stress, but this expression is not present in male mice