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Sternberg, P

The degradation of the upper motor neurons leads to spasticity and hyper-excitability, while the death of the lower motor neurons causes weakness, fasciculations and eventually muscular atrophy followed by progressive paralysis

Docking of the HPV-16 E7 dimer with the GSTP1 monomer was performed using the program Hex v4.5 (Department of Computing Science, University of Aberdeen, Aberdeen AB24 3UE, Scotland, UK

However, conformations of the linker loops among the three structures are drastically different, suggesting that the flexible VD linker may not be optimal for crystallization of some targets such as the IGBP1-CARD and NLRP1-PYD

Volume of distribution was 0.33 l/kg, consistent with distribution mainly to extracellular water