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GLP-1 use is safe and effective with many pre-existing conditions with the exception of the following: Currently pregnant Currently breastfeeding Currently being treated for cancer Active eating disorder Active gallbladder disease Active substance abuse or dependency Type 1 diabetes Bariatric surgery (within the past 18 months) Pancreatitis within the past 6 months, or a history of pancreatiitis caused by taking a GLP-1 Personal or family history of medullary thyroid cancer or MEN syndrome Personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

[63] A Stanford University School of Medicine meta-analysis of clinical studies on the subject published in early 2007 showed that the application of GH on healthy elderly patients increased muscle by about 2 kg and decreased body fat by the same amount

10.1021/np2003512 51 HongS.Moreno-NavarreteJ

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