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5.6 What has actually worked in PC nanomedicine and why (and what failed) Despite thousands of preclinical studies and significant investments in the clinical translation of nanomedicines for PC, only two nanoformulations, namely nanoparticle albumin-bound paclitaxel (nab-paclitaxel, Abraxane ) and nanoliposomal irinotecan (Onivyde ), have been approved by the FDA and EMA for the treatment of pancreatic cancer (PC) (124,181)

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