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In patients with renal, cardiac or hepatic impairment, caution is required since the use of NSAIDs may result in deterioration of renal function

Abstract Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids 1,2

Accumulated AGEs bind to membrane receptors on endothelial cells and promote the onset of tissue damage and the activation of the proinflammatory pathway that involves the NFB transcription factor responsible for regulating the expression of other inflammatory cytokines (Figure 4) [37]

Anyone interested in pharmacological support for weight management should speak with their GP or be referred to an NHS Tier 3 weight management service, where appropriate assessment and supervised care can be provided safely and legally