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For example, a PD-1 polypeptide is an inhibitory receptor capable of transmitting an inhibitory signal to an immune cell to thereby inhibit immune cell effector function, or capable of promoting co-stimulation (e.g., by competitive inhibition) of an immune cell, e.g., when present in a soluble monomeric form

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This dual anti-inflammatory + antimicrobial action makes it particularly relevant for research models on skin pathologies where inflammation and infection coexist (Kannengiesser et al., 2017)

Yang Y, Luo Y, Yuan J, Tang Y, Xiong L, Xu M, et al

Oncogene 20 (2), 167177