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& Taegtmeyer, H

One of the more surprising findings of the present studies was the relatively small amount of d 3 -BB found in plasma compared with d 3 -TMAO after d 3 -l-carnitine challenge, especially after ex vivo fecal studies showed that BB is a major metabolite of l-carnitine produced by human fecal polymicrobial cultures (43)

2010 Mar;35(3):437-43

36 Gut Microbiome Imbalances Imbalances in gut microbiome composition may result in problems with lipid and glucose metabolism, increased intestinal permeability, and liver inflammation and fibrosis

It wasn't until the 1960s and 1970s that spirulina, rich in vitamins and minerals, began to be used on an industrial scale