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This change leads to a substitution of glutamic acid (E) with lysine (K) at position 167 (E167K, p.Glu167Lys) [267]

For instance, Sheiha et al

doi: 10.1186/s12951-025-03197-1, 30

Seek immediate, emergency care and call 911 if you: Lose consciousness or pass out Have difficulty breathing or are short of breath Call your doctor if you have: Your original symptoms from before surgery A high fever Nausea and cannot drink fluids Worsening or severe pain, even with medications Discharge, redness, warmth, or increasing swelling from the wound Red streaks around the incision Bright red blood soaking through the bandage Loose stitches or your incision opens Jaundice, or yellowing skin or eyes Dark urine or whiteish stools, or cannot pass stools or gas Signs of a potential blood clot (swelling or pain in the legs) These could be signs of an infection or a gallbladder surgery complication

Despite the negative outcomes of these studies, edaravone (Radicava), was recently approved by the USFDA (Takei et al., 2017b