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S., Li, B., Vachali, P

Homozygous mutation in leptin receptor (LEPR) results in early onset of obesity (due to hyperleptinemia) and this leads to several endocrine abnormalities including hyperinsulinemia (237)

Seriously, she said in part

Stress oxydatif : L'accumulation de radicaux libres peut acclrer le vieillissement de la peau, entranant des problmes tels que les rides et la pigmentation