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Detection of occult acute kidney injury in glucose-6-phosphate dehydrogenase deficiency anemia

In addition, recent studies using liver-specific Zip14 KO mice displayed an almost complete loss of hepatic Mn, demonstrating that ZIP14 is the primary transporter responsible for Mn uptake into the liver (Xin et al., 2017

Additionally, polymorphisms in GPX1 (e.g., Pro198Leu, rs1050450) have been associated with decreased enzymatic activity and increased OS, potentially exacerbating autoimmune thyroid conditions

This discrepancy of iron chelation worsening neurodegeneration characterised by local iron overload raises a critical question: why does iron chelation block ferroptosis induced by pro-ferroptotic agents such as RSL3 and erastin (where there is no iron elevation in cell culture), yet fail to protect in the context of human neurodegenerative disease where iron is elevated

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