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Grealish and others found that grafts of human ES cell-derived dopaminergic neurons placed in a mouse were effective, axonal regeneration is possible in the rat model of PD as well as functional growth and long-term survival efficacy more than the human foetal mesencephalic dopaminergic neurons (Grealish et al., 2014)

Cyclosporin treatment has been demonstrated to upregulate pro-inflammatory cytokines TNF-, IL-1, and NF-B, contributing to hepatic inflammation and tissue damage