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Thus, it is important that a chelator satisfy criteria that allow it to: (1) transport across physiological barriers into compartments where a toxic metal ion is concentrated, (2) form a stable complex with the metal after removing it from the biological chelator, if required at the site and (3) form a chelation complex whose properties render it non-toxic and facilitate its excretion, not only from the site of deposition, but also from the body [3]

There are 2 major subtypes of DMARDs - Non-Biologic & Biologic: Non-Biologic DMARDs exert their effects by relatively nonspecific immunosuppressive, antiinflammatory and cytotoxic mechanisms

10.1016/j.phrs.2021.105482 91 WangX.FisherD.PronyukK.DangY.ZhaoL

PMID 17557503