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Oral health in geroscience: animal models and the aging oral cavity

shows that 7nAChRs knockout mice that do not respond to cholinergic agonists, which in turn enhance the production of several cytokines and inflammatory markers, including tumor necrosis factor-alpha (TNF-) and interleukin-1 (IL-1) [65], this results from suppression of signal transduction cascade including PIK3/Akt and Nrf2 and upregulation of NF-B that represent a transcriptional factor capable of coordinating the inflammatory response, regulating the inflammatory gene expression [35, 66]

The purported existence in the matrix of in vitro biofilm-specific proteins has, however, been reported providing some evidence that biofilm formation does occur 17

Pierre-Eugene C, Pagesy P, Nguyen TT et al (2012) Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2

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