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Substituted sulfonyl refers to the group -S0 2 -alkyl, -S0 2 -substituted alkyl, -SO2-OH, -SC -alkenyl, -SC -substituted alkenyl, -SC -cycloalkyl, -SC -substituted cylcoalkyl, -SC -aryl, -SO2- substituted aryl, -SC -heteroaryl, -SO2- substituted heteroaryl, -SC -heterocyclic, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein

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