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Takewaki, D

Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations

Trials using NAC have been carried out lasting for up to 60 months in psychiatric disorders, but there is limited research on long-term trials in PD and whether NAC could be used for an extended period in PD remains unclear

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Furthermore, due to their limited absorption in the upper gastrointestinal tract, these polyphenols reach the colon, where they undergo extensive microbial biotransformation