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Bempedoic acid, a notable ACLY inhibitor, effectively reduces lipid levels and received FDA approval in 2020 as a cholesterol-lowering drug

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Additionally, research has explored NAD+'s role in acute neurological injuries such as stroke and traumatic brain injury using experimental models, with studies suggesting that rapid NAD+ depletion following brain injury contributes to neuronal death and that NAD+ restoration may be neuroprotective in research models

doi: 10.1021/cr200084z 37 YoshidaYUmenoAShichiriM