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Da bestimmte therapieresistente Tumore, speziell auch solche, die eine Entdifferenzierung durchlaufen sind, einen Ferroptose-sensitiven Zustand entwickeln, mssen pro-ferroptotische Behandlungsparadigmen, die auf dem Hemmen von FSP1, GPX4 oder einer Kombination davon beruhen, knftig in der Klinik Anwendung finden

Further research discovered that the negative regulation of MDSC functions by AIMP1 might be related to the weakened activation of STATs, protein kinase B (Akt) and ERK

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Curcumin induces mitochondrial apoptosis in human hepatoma cells through BCLAF1-mediated modulation of PI3K/AKT/GSK-3 signaling

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