glutathione and glutamate cysteine liaase Cysteine, Glutathione, Thiol Redox Balance in Astrocytes Glutamate cysteine ligase and the

MST1/2 can sense ROS and protect macrophages from oxidative stress by regulating the stability of the transcription factor Nrf2, which is a key transcriptional activator of the antioxidant response in macrophages

The prevalence of the 718TC and 718CC genotypes of the GPX4 gene was higher in the EHCS group as compared with the EH group (OR=2.12, 95%CI 1.423.16, P =0.0002, P adj =0.0018)

H.GuoL.et al

8 The body requires a delicate balance between production and detoxification/transport of harmful reactive species and protein adducts, and when these defenses are overwhelmed at hepatotoxic doses of APAP, the glucoronidation and sulfonation pathways become saturated, pushing the majority of APAP to be metabolized to NAPQI by the CYP 2E1 pathway and resulting in GSH depletion and build-up of toxic NAPQI

Ruvolo PP, Ma H, Ruvolo V, Zhang X, Mu H, Yasuhiro T, Tanaka K, Yoshizawa T, Zhang W, Cortes JE, Andreeff M , Post SM