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(2) Reactive oxygen species affects NP by mediating central sensitization, which is an increase in sensitivity to peripheral afferents in spinal pain-associated conductance neurons after NP develops

doi: 10.1371/journal.pone.0231865 89 GaoGLiCFanWZhangMLiXChenWet al

Llanos AA, Brasky TM, Dumitrescu RG, Marian C, Makambi KH, Kallakury BVS, et al

Zhang H, Zhao Y, Yu M, Zhao Z, Liu P, Cheng H et al (2019) Reassembly of native components with donepezil to execute dual-missions in Alzheimers disease therapy