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and aberrant in vivo PK/PD behavior confounds therapeutic prediction and dosing regimens [35]

Impact of dietary supplementation of beef cows with rumen-protected methionine during the periconceptional period on post-weaning performance of female offspring

Doses of magnesium that may have been too low to have a therapeutic effect on the brain

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Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (70)