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Diabetologia (2012) 55:84554

For example, the recommended doses can vary from 500 mg to 2000 mg per day, considering factors such as how it is administered and individual health needs

6 Toxicity and adverse reactions Acute toxicity tests indicated that albino mice with a single oral dose of 2,000 mg/kg of GA did not exhibit any toxicological conditions

doi: 10.1016/j.biopha.2018.03.129 89 MezaCALa FavorJDKimDHHicknerRC

Chemical synthesis of these compounds would require not only the preparation of the (2 S ,3 S )- t -ES monoester but also subsequent multistep synthesis with protectiondeprotection steps 6 (Supplementary Fig