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Patients should be counseled to store the medication away from the freezer compartment and to be aware of areas in their refrigerator that may be prone to freezing

Pain treatment should therefore begin with an adjustment of dopaminergic medications whenever pain is reckoned to depend upon insufficient dopaminergic stimulation and progressively integrate pharmacological measures targeting any identified cause of nociceptive or neuropathic pain, until an adequate symptomatic control is achieved