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Rabbits were bled at weeks 0, 4, and 6

HbA1c measures average blood glucose over 812 weeks via glycated haemoglobin, whilst fasting insulin measures circulating insulin after an overnight fast to help detect insulin resistance before glucose levels become abnormal

Cell Death Differ (2020) 27(3):85871

subjects using any topical imiquimod, 5-fluorouracil, or diclofenac on their neck within three months prior to or during the study period

Therefore, any research studies using these ingredients should be carefully designed to monitor for potential adverse reactions, and the concentration of these research compounds should be optimized to balance efficacy and safety