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high pharmacologic doses (1-3 g/day) can cause hypotension, insulin resistance, and hepatotoxicity

This disruption promotes fatty liver disease and hepatocellular carcinoma through interference with critical processes such as autophagy ( Table 3 )

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Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp 70 S6 kinase, DNA synthesis, and glucose transporter translocation