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The primers used for the construct preparation are listed in Table S1

For example, the inhibition of histone deacetylases or demethylases interferes with the chromatin modifications that maintain DTP cells in a drug-tolerant state, such as the retention of closed or repressed chromatin at pro-apoptotic loci, thereby restoring susceptibility to drug-induced apoptosis (55)

After 5 washes, 90-L of TMB substrate solution was added into each well, incubated for 20 min at 37 C

Nau R, Srgel F, Eiffert H (2010) Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections

Autophagy can prevent toxic accumulation of cell waste, protect organelles and maintain cell survival