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But the mechanistic rationale is strong, the safety profile appears favorable, and the early observational data aligns with what the biochemistry predicts

When subjected to mechanical stress, such as that induced by a steep tibial slope, these cross-links can become disrupted, leading to weakened fibril structure and reduced overall ligament strength

ROS subsequently modifies and interferes with proteins, lipids, and DNA, which can induce cell death

Thus, when drugs are applied topically, their local bioavailability is reduced, as expected

Cells import cystine from the blood, reconvert it to cysteine (likely using ascorbate as cofactor), and from it synthesize GSH