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Aim: The SAFE-D project aims to determine whether a randomised trial of warfarin, apixaban or no oral anticoagulation is feasible, in terms of recruitment, adherence to the protocol, and adequacy of follow up in patient with atrial fibrillation receiving dialysis

Laboratory and animal studies have investigated telomerase, telomere length, melatonin rhythms, ageing biomarkers, retinal degeneration and tumour development

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Additional studies are needed to validate the biomarkers in a clinical setting

The effects vary and should be monitored under medical guidance