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ND-646, an allosteric inhibitor of ACC1 and ACC2, has been shown to suppress tumor growth in non-small cell lung cancer (NSCLC) xenograft models

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The improved OS outcomes observed across multiple tumor response evaluations, including disease control and depth of response, provide novel insights on the clinical benefit of dual immune checkpoint inhibition beyond conventional measures of response

Even if clinical trials suggest tolerability, the real-world risk profile changes when: the source and purity of the peptide are uncertain, its used in different routes than studied, its used in stacked protocols with other drugs, its used in populations the trials didnt represent

First, it could increase the risk of infection because the ACE2 receptor is reported as a critical factor for intracellular entry of the virus (211)