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FIGURE 1 Although both isoforms of the nuclear estrogen receptor (ER), ER-alpha and ER-beta, are expressed in all parenchymal endometrial cell types (including glandular epithelial and stromal) across all phases of the menstrual cycle, ER-alpha is the predominant form uniformly (Matsuzaki et al., 1999)

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After reading a report that phosphatidylinositol 3-phosphate and phosphatidylinositol 4-phosphate have opposing effects on mTORC1 activity in cells 26 , we tested these lipids in the in vitro kinase assay (Extended Data Fig