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The hypothesis of an effect of testosterone rise in the l-ARG-mediated improvement of penile erectile function, at least in the mildmoderate vasculogenic ED patients enrolled within the current study, might be partially supported by the evidence of a trend towards increased testosterone levels upon l-ARG supplementation in the overall l-ARG cohort, although testosterone levels were not significantly improved and were already within the normal range at baseline, therefore partially smoothening this hypothesis

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Furthermore, our study revealed that Tibetan M9a+sh EPAS1 cells exhibited the most robust mitochondrial function, supporting the hypothesis of increased oxygen transport and utilization capacity in Tibetans [36, 37]

At the standard starting dose of 0.25mg per week, a single 5mg vial provides 20 individual doses