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This pharmacologically inactive N-acetylated mesalazine is mainly excreted into the urine [17, 20]

CONCLUSION: The prevalence of the 16189 variant in the Korean is higher than in the Caucasian but the same as in the Japanese

Notably, gut microbiota metabolites suppress intestinal epithelial Hypoxia-inducible factor-2 alpha (HIF-2) activity and reduce the expression of FTN and, thus, regulate the host iron absorption pathway (Mao et al., 2024)