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Adaptive Immunity in SSc T Cells in SSc Skin Compared to healthy skin, T cells are abundant in involved SSc more so early in disease course and active collagen synthesis is more pronounced around inflammatory infiltrates [150, 151]

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In healthy volunteers, anodal stimulation consistently increased pain thresholds and reduced pain-related evoked potentials, whereas cathodal stimulation either enhanced pain sensitivity or produced no change (15, 16, 19)

Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons