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Cell 82 , 32703283.e3279 (2022)

Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF (2005) New hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

Using in vitro systems and animal based models, these studies have focused on characterizing receptor specificity, intracellular signaling fidelity, and the temporal organization of hormone secretion

This "maintenance" function slows when GH declines, contributing to the gradual deterioration we experience as aging