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Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them

In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]

290 , R1421R1428 (2006)