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Compared to vasculature elsewhere in the body, tumor vasculature is typically erratic and highly dysfunctional, characterized by blunt ends and inconsistent blood flow, resulting in insufficient tumor perfusion and high interstitial pressure (9497)

J Neurochem 61(4):14381444 Saha L, Bhandari S, Bhatia A, Banerjee D, Chakrabarti A (2014) Anti-kindling effect of bezafibrate, a peroxisome proliferator-activated receptors alpha agonist, in pentylenetetrazole induced kindling seizure model

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The dramatically reduced serum T4 and T3 levels that accompany dieting are associated with an increase in pituitary T3 receptor saturation (i.e., percentage of activated T3 receptors), which results in a decrease in TSH even when serum thyroid hormone levels were reduced by 50%

Since then, our understanding of free radicals involvement in living processes has expanded significantly