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Surgery for Piriformis Syndrome Surgery for piriformis syndrome is rare and is only recommended for severe cases that have not responded to nonsurgical treatments for several months and progressed over time

Altitude increases fluid loss through faster breathing and increased urination, which reduces total body water independently of alcohol

Vitamin B12 deficiency can be occurring while vitamin B12 levels are at levels not typically associated with deficiency due to the presence of deleterious MTHFR mutations

Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity

It is also linked to lower glucagon release after meals, which can improve glycemic stability