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Description

Transgenic mice overexpressing protein kinase C in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion

D.HortonJ

More particularly, this invention relates to such process, wherein (S)-3-activated hydroxybutyrolactone is utilized as a raw material so as to undergo the following chemical reactions under the specific conditions: a ring-opening reaction, epoxydation where the chiral center is inversely converted, and nucleophilic substitution of trimethylarmine