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Wnt signaling in stem cell regulation and tissue regeneration In contrast to the Wnt/Frizzled/-catenin axis, which is evolutionarily conserved from early multicellular animals and onward, the R-spondin/Lgr gene families are primarily a vertebrate specific evolutionary addition

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It is noted that the systemic administration of immunotherapeutic agents may destroy the homeostatic function of immune cells in non-target tissues, therefore a local delivery vehicle could allow for modulation and sustained release of the payload, which thereby would not only minimize off-target related side effects, but also enhance effective drug bioavailability