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Yafeng Chen, [email protected] These authors contributed equally to this work and share first authorship These authors have contributed equally to this work and share last authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, existing research faces several challenges

They each serve discrete purposes

However, some case reports suggest that melanotic macules might carry a risk of developing into oral melanoma

however, in hypercatabolic states (such as severe burn wounds, infections, and surgery