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Based on molecular docking analysis, computation toxicity studies, and the cheminformatics properties, we observe that the two metabolites desethylchloroquine and bisdesethylchloroquine have similar binding modes of action and drug-like properties albeit with significantly lower toxicity values compared to the parent CQ and HCQ molecules

With age, antioxidant levels are generally thought to decline, so the body cannot protect itself from environmental exposures as well as it can when you are young

Myeloperoxidase Myeloperoxidase (MPO) is synthesized in neutrophils and monocytes and catalyzes the conversion of hydrogen peroxide to hypochlorous acid (HOCl) (Siraki 2021)

TrxRs are crucial to maintain the small antioxidant protein thioredoxin in its reduced state (Arner, 2009)

Simple Math Blunders: It happens to the best of us, especially at the end of a long day in the lab