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Phosphatidylcholine 36:1 Concentration Decreases Along With Demyelination in the Cuprizone Animal Model and in Post-Mortem Multiple Sclerosis Brain Tissue

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Autotomy that occurs long after injury may appear as pain that occurs below the level of the injury (below-level pain) [64, 65], and the late spontaneous worsening may be the result of complete deafferentation of one or several spinal segments the stimulation of the nerve plexus, or dorsal root injury [66]

That is not a weakness in the research it is an accurate reflection of how complex the condition is