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Before obvious clinical symptoms appear in AD patients, increased BBB permeability occurs in many brain regions, including the hippocampus, cortex, deep gray matter, and white matter by Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) [146,147,148,149]

HIF1 was strongly expressed and present in the nucleus of many cells in the whole E10.5 cortex and in the dorsal cortex at E11.5, but overall reduced and excluded from the nucleus concomitant with the progression of vessel formation throughout the cortex (Figs 4GI'' and EV1IK)

Some chronic or severe injuries require extended protocols beyond typical 12-week durations